Mean alcohol cue-elicited activation (ALC – BEV) in each medication group. Figures are means (arbitrary units ± standard errors) from hierarchical linear models that included medication, cigarettes per day, age, family history of alcoholism, and baseline percent heavy drinking days. Varenicline (VCL), relative to placebo (PLA), significantly reduced ALC – BEV activation in left and right orbitofrontal cortex (OFC), but there were no significant between-groups differences in ALC – BEV activation of medial OFC, right ventral striatum (VS), or medial prefrontal cortex (mPFC). ** p < 0.005.