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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Cell Microbiol. 2014 Jun 2;16(9):1405–1424. doi: 10.1111/cmi.12302

Table 3.

Actin pedestal formation promotes lethal infection.

Range of
fecal
shedding
(log)		 Cr (Φstx2dact)Δtir/pTirWT Cr (Φstx2dact)Δtir/pTirY471F
Average
log fecal
shedding		 % Lethality
(# dead/total)		 Average log
fecal
shedding		 % Lethality (#
dead/total)
9.7-10.7 9.8 80% (4/5) na na
9.1-9.7 9.3 91% (10/11) 9.4 100% (1/1)
8.3-9.1 8.8 53% (8/15) 8.8 0%* (0/5)
7.7-8.3 8.0 60% (3/5) 8.0 0%* (0/8)
Below 7.7 4.8 0% (0/4) 7.4 0% (0/6)
Total 8.8 62.5% (25/40) 8.1 5% (1/20)
*

statistically significant defect in lethality compared to mice infected with C. rodentium (Φstx2dact)Δtir/pTirWT (p<0.05).

na, not applicable.