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Conditions attempted for the Heck cyclization.
| Conditions | Outcome |
|---|---|
| Pd(dppf)2Cl2, dppf, Ag3PO4 dioxane, 60°C, 24 h | No reaction |
| Pd(OAc)2, dppe, Ag3PO4, Et3N toluene, 80°C, 18 h | Traces of 18 |
| Pd(OAc)2, PPh3, Et3N, AgNO3, MeCN, 24 h, r.t to 80°C | No reaction |
| Pd(OAc)2, dppe, AgNO3, Cs2CO3, toluene, 24 h, 110°C | 18, 35% (45 % brsm) |
| Pd(OAc)2, BINAP, Ag3PO4, Et3N toluene, 80°C, 18 h | No reaction |
