Table 1. Participant Characteristics at Baseline (Means±Standard Deviation).
| TOP | PLA | |
|---|---|---|
|
|
||
| n (female) | 14 (1) | 16 (1) |
| Age [years] | 49.5±13.9 | 50.4±12.8 |
| Education [years] | 12.9±3.1 | 14.4±1.9 |
| Race | ||
| Caucasian (Hispanic/Latino) | 8 (2) | 8 |
| American Indian/Alaskan Native | 1 | 0 |
| Asian | 1 | 1 |
| African American | 2 | 5 |
| Pacific Island Native | 0 | 1 |
| Mixed Race | 2 | 1 |
| Combat Exposed, n (%) | 10 (71) | 12 (75) |
| Comorbid Substance Use Disorder, n (%) | 5 (36) | 5 (32) |
| AUD Residential TX, n (%) | 4 (29) | 2 (13) |
| AUD Outpatient TX, n (%) | 7 (50) | 8 (50) |
| PTSD Outpatient TX, n (%) | 9 (65) | 9 (56) |
| PTSD Pharmacotherapy TX, n (%) | 5 (37) | 9 (56) |
| Alpha Blocker [Prazosin] (%) | 1 (7) | 1 (6) |
| Antidepressants (%) | 4 (29) | 7 (44) |
| Buproprion (%) | 0 (0) | 1 (6) |
| Citalopram (%) | 2 (14) | 3 (19) |
| Fluoxetine (%) | 0 (0) | 1 (6) |
| Mirtazapine (%) | 1 (7) | 0 (0) |
| Setraline (%) | 0 (0) | 2 (13) |
| Venlafaxine (%) | 1 (7) | 0 (0) |
| Antipsychotic [Quetiapin] (%) | 1 (7) | 1 (6) |
| Anxiolytic (%) | 0 (0) | 2 (13) |
| Buspirone (%) | 0 (0) | 1 (6) |
| Hydroxyzine (%) | 0 (0) | 1 (6) |
| Beta Blocker [Propranolol] (%) | 0 (0) | 1 (6) |
| Sedative/Hypnotic (%) | 0 (0) | 3 (19) |
| Temazepam (%) | 0 (0) | 1 (6) |
| Trazodone (%) | 0 (0) | 2 (13) |
| Stimulant [Ritalin] (%) | 1 (7) | 0 (0) |
| BDI | 23.4±11.6 | 26.3±12.3 |
| BAI | 20.4±12.7 | 27.4±13.3 |
| AUDIT Score | 27.1±7.9 | 23.0±7.5 |
| Days Abstinent Between Last Drink and Initiation of Study Medication | 12.8±13.6 | 4.8±9.2 |
| Percent DD per Week | 73.3±30.3 | 80.4±21.5 |
| Percent HDD per Week | 58.5±33.7 | 72.6±28.5 |
| Avg. Drinks$ per Week | 52.4±34.2 | 58.2±25.4 |
| Avg. Drinks$ per DD | 11.1±6.1 | 10.9±4.7 |
| Baseline CAPS Total | 72.8±14.3 | 83.1±17.3 |
| Reexperiencing | 18.2±4.3 | 21.9±6.9 |
| Avoidance | 31.1±6.1 | 34.8±8.9 |
| Arousal | 23.5±6.7 | 26.4±4.1 |
Abbreviations: AUD, Alcohol Use Disorder; BDI, Beck Depression Inventory; BAI, Beck Anxiety Inventory; CAPS, Clinician Administered PTSD Scale; %DD, percent drinking day; HDD, heavy drinking day (>4 standard alcoholic drinks for men, >3 standard alcoholic drinks for women). Drink consumption was averaged over 90 days preceding study consent.
$
standard alcoholic drink is defined as containing 13.6 g of pure alcohol