Table 1. Participant Characteristics at Baseline (Means±Standard Deviation).
TOP | PLA | |
---|---|---|
|
||
n (female) | 14 (1) | 16 (1) |
Age [years] | 49.5±13.9 | 50.4±12.8 |
Education [years] | 12.9±3.1 | 14.4±1.9 |
Race | ||
Caucasian (Hispanic/Latino) | 8 (2) | 8 |
American Indian/Alaskan Native | 1 | 0 |
Asian | 1 | 1 |
African American | 2 | 5 |
Pacific Island Native | 0 | 1 |
Mixed Race | 2 | 1 |
Combat Exposed, n (%) | 10 (71) | 12 (75) |
Comorbid Substance Use Disorder, n (%) | 5 (36) | 5 (32) |
AUD Residential TX, n (%) | 4 (29) | 2 (13) |
AUD Outpatient TX, n (%) | 7 (50) | 8 (50) |
PTSD Outpatient TX, n (%) | 9 (65) | 9 (56) |
PTSD Pharmacotherapy TX, n (%) | 5 (37) | 9 (56) |
Alpha Blocker [Prazosin] (%) | 1 (7) | 1 (6) |
Antidepressants (%) | 4 (29) | 7 (44) |
Buproprion (%) | 0 (0) | 1 (6) |
Citalopram (%) | 2 (14) | 3 (19) |
Fluoxetine (%) | 0 (0) | 1 (6) |
Mirtazapine (%) | 1 (7) | 0 (0) |
Setraline (%) | 0 (0) | 2 (13) |
Venlafaxine (%) | 1 (7) | 0 (0) |
Antipsychotic [Quetiapin] (%) | 1 (7) | 1 (6) |
Anxiolytic (%) | 0 (0) | 2 (13) |
Buspirone (%) | 0 (0) | 1 (6) |
Hydroxyzine (%) | 0 (0) | 1 (6) |
Beta Blocker [Propranolol] (%) | 0 (0) | 1 (6) |
Sedative/Hypnotic (%) | 0 (0) | 3 (19) |
Temazepam (%) | 0 (0) | 1 (6) |
Trazodone (%) | 0 (0) | 2 (13) |
Stimulant [Ritalin] (%) | 1 (7) | 0 (0) |
BDI | 23.4±11.6 | 26.3±12.3 |
BAI | 20.4±12.7 | 27.4±13.3 |
AUDIT Score | 27.1±7.9 | 23.0±7.5 |
Days Abstinent Between Last Drink and Initiation of Study Medication | 12.8±13.6 | 4.8±9.2 |
Percent DD per Week | 73.3±30.3 | 80.4±21.5 |
Percent HDD per Week | 58.5±33.7 | 72.6±28.5 |
Avg. Drinks$ per Week | 52.4±34.2 | 58.2±25.4 |
Avg. Drinks$ per DD | 11.1±6.1 | 10.9±4.7 |
Baseline CAPS Total | 72.8±14.3 | 83.1±17.3 |
Reexperiencing | 18.2±4.3 | 21.9±6.9 |
Avoidance | 31.1±6.1 | 34.8±8.9 |
Arousal | 23.5±6.7 | 26.4±4.1 |
Abbreviations: AUD, Alcohol Use Disorder; BDI, Beck Depression Inventory; BAI, Beck Anxiety Inventory; CAPS, Clinician Administered PTSD Scale; %DD, percent drinking day; HDD, heavy drinking day (>4 standard alcoholic drinks for men, >3 standard alcoholic drinks for women). Drink consumption was averaged over 90 days preceding study consent.
standard alcoholic drink is defined as containing 13.6 g of pure alcohol