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. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: Circulation. 2014 Jun 20;130(9):768–775. doi: 10.1161/CIRCULATIONAHA.114.009690

Table 2.

Treatment assignment has a significant effect on change in hemodynamics at 12 weeks (Criterion #1)

Hemodynamic measure Mean difference between treatment and placebo 95% CI P value
ΔRAP −1.2 mm Hg −1.8, −0.6 < 0.001
ΔmPAP −2.4 mm Hg −3.4, −1.3 0.003
ΔCO 0.37 L/min 0.24, 0.50 < 0.001
ΔCI 0.22 L/min/m2 0.14, 0.29 < 0.001
ΔPVR −2.1 Wood units −2.7, −1.5 < 0.001
ΔPA compliance 0.15 mL/mm Hg 0.09, 0.21 < 0.001

All models include adjustment for baseline hemodynamic value and study. CI=confidence interval; ΔRAP=change in right atrial pressure; ΔmPAP=change in mean pulmonary artery pressure; ΔCO=change in cardiac output; ΔCI=change in cardiac index; ΔPVR=change in pulmonary vascular resistance; ΔPA compliance=change in pulmonary artery compliance.