Skip to main content
. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: Circulation. 2014 Jun 20;130(9):768–775. doi: 10.1161/CIRCULATIONAHA.114.009690

Table 4.

Treatment assignment has a significant effect on the odds of a clinical event (Criterion #3) and the change in the odds of a clinical event when a given hemodynamic mediator is added to the model (Criterion #4)

Criterion #3 Criterion #4
Baseline hemodynamic measure OR active treatment vs. placebo 95% CI P value OR active treatment vs. placebo when mediator added to model Absolute change in OR when mediator is added to model
RAP 0.43 0.28, 0.66 < 0.001 0.44 0.01
mPAP 0.48 0.31, 0.72 < 0.001 0.48 0.00
CO 0.48 0.32, 0.74 < 0.001 0.53 0.05
CI 0.49 0.32, 0.74 < 0.001 0.53 0.04
PVR 0.47 0.30, 0.72 < 0.001 0.52 0.05
PA compliance 0.48 0.31, 0.73 < 0.001 0.49 0.01

All models include adjustment for the listed baseline hemodynamic value and study. OR=odds ratio; CI=confidence interval; RAP=right atrial pressure; mPAP=mean pulmonary artery pressure; CO=cardiac output; CI=cardiac index; PVR=pulmonary vascular resistance; PA=pulmonary artery.