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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Neurosci. 2014 Jul 27;17(9):1240–1248. doi: 10.1038/nn.3767

Figure 1. CEl PKC-δ+ neurons are activated by diverse anorexigenic signals.

Figure 1

a, d-e. Representative histology (a) and quantification (d-e) of c-Fos like immunoreactivity in CEl after intraperitoneal injection of saline, CCK, LiCl, or LPS. b, f-g. Histology (b) and quantification (f-g) of CEl c-Fos expression in 24 h fasted mice with or without 3 hr refeeding. c, h-i. Histology (c) and quantification (h-i) of CEl c-Fos expression in mice with oral infusion of water, quinine, or sucrose solution. Box plots (d, f, h) show mean (+), median, quartiles (boxes), and range (whiskers) in each CEl brain section; Values in (e, g, i) are means ± s.e.m. n = 6 – 17 brain sections from 4 – 5 animals in each condition. One-way ANOVA (F(3, 24) = 45.5, p < 0.0001 (d); F(2, 36) = 73.2, p < 0.0001 (h)) with post-hoc Bonferroni t-test indicated a significant difference between the saline-injected and drug-injected groups; Unpaired t-tests are used in (e), t(12) = 6.85, p < 0.0001 (CCK), t(12) = 7.03, p < 0.0001 (LiCl), t(14) = 1.00, p = 0.33 (LPS); t(30) = 8.43, p < 0.0001 (f); t(32) = 8.09, p < 0.0001 (re-fed) (g); t(28) = 3.42, p = 0.0019 (quinine) (i). n.s. not significant, ** p < 0.01, *** p < 0.001.