Figure 1.
Liver histology. Representative hematoxylin and Sudan III staining of flox/flox, ΔL Fxr and ΔIE Fxr knockout mice under control diet and 1% cholesterol diet (left panel). Representative BODIPY staining of flox/flox, ΔL Fxr and ΔIE Fxr knockout mice under control diet and 1% cholesterol diet are shown in a lower magnification (right panel). Massive lipid accumulation can be seen in ΔL Fxr knockout mice under 1% cholesterol diet. Insert shows tissue in a higher magnification. Scale bars: 10 μm.