Table 1.

Controlled trials of CBT in adults with irritable bowel syndrome

Authors	Design	Sample size	Outcome
Corney et al[62] (1991)	CBT vs SMT. FU at 4 & 9 mo	42	CBT = SMT
Greene et al[64] (1994)	CBT vs SMT. FU at 3 mo	20	CBT > SMT
Payne et al[65] (1995)	CBT vs Self-help support group vs SMT. FU at 3 mo	34	CBT > Self-help > SMT
Drossman et al[68] (2003)	CBT vs education, and desipramine vs placebo (parallel studies). No FU	431	CBT > education; desipramine: placebo
Boyce et al[61] (2003)	CBT vs relaxation training vs SMT. FU at 12 mo	105	CBT = Relaxation training = SMT
Blanchard et al[66] (2007)	Group CBT vs Self-help support group vs SMT. FU at 3 mo	210	CBT = Support group > SMT
Kennedy et al[63] (2006)	Multicenter primary care intervention by nurses. Open label. CBT + mebeverine vs mebeverine alone.	149	CBT + mebeverine > Mebeverine alone at 3 & 6 mo FU

SMT: standard medical care with symptom self-monitoring; FU = follow up; Mebeverine: anticholinergic for inhibition of smooth muscle contractions.