uPA/SCID mice |
Human hepatocyte transplantation |
1 × 104 to 8 × 107 copies/mL |
Up to 9 mo with maximum viremia as from one month |
High viremia |
Variability of primary human hepatocytes |
Mercer et al[26] 2001 |
Meuleman et al[22] 2005 |
Immunosuppressed mice |
Kneteman et al[29] 2006 |
Trimera mice |
Xenograft of human liver tissue |
Around 7 × 104 copies/mL |
Around one month with peak viremia at 18 d |
Low viremia |
Variability of human liver tissues |
Ilan et al[12] 2002 |
Immunosuppressed mice |
Eren et al[11] 2006 |
Rat |
Immunotolerization and transplantation of a human hepatoma cell line |
1-2 × 104 copies/mL |
Minimum 4 mo with peak viremia at 3 mo |
Low viremia |
Transplantation of a hepatoma cell line |
Wu et al[8] 2005 |
Immunocompetent rat |