Figure 2.

Algorithm for treatment of HCV-positive mixed cryoglobulinemia patients with antiviral therapy according to the evaluation of both mixed cryoglobulinemia syndrome and chronic liver damage. Available data suggest that antiviral therapy should be considered the first choice treatment in mixed cryoglobulinemia, to be performed even in the absence of different indications, excluding only those patients without symptoms and other indications or patients with too severe manifestations such as acute nephritis or widespread vasculitis. (Zignego AL, Postgraduate Course EASL 2006, Vienna and [34], modified)