Table 1.

Classification of extrahepatic manifestations of HCV infection

A: Association defined on the basis of high prevalence and pathogenesis
Mixed cryoglobulinemia (complete or incomplete clinical syndrome)
B: Association defined on the basis of higher prevalences than in controls
B-cell non-Hodgkin’s lymphoma
Monoclonal gammopathies
Porphyria cutanea tarda
Lichen planus
C: Associations to be confirmed/characterized
Autoimmune thyroiditis
Thyroid cancer
Sicca syndrome
Alveolitis-Lung fibrosis
Diabetes mellitus
Non-cryoglobulinemic nephropathies
Aortic atherosclerosis
D: Anecdotal observations
Psoriasis
Peripheral/central neuropathies
Chronic polyarthritis
Rheumatoid arthritis
Polyartheritis nodosa
Bechet’s syndrome
Poly/dermatomyositis
Fibromyalgia
Chronic urticaria
Chronic pruritus
Kaposi’s pseudo-sarcoma
Vitiligo
Cardiomyopathies
Mooren corneal ulcer
Erectile dysfunctions
Necrolytic acral erythema