Table 2.
IFN monotherapy in HCV-related mixed cryoglobulinemia
| Author | Year | No. patients | Treatment | CS | Treatment duration (months) | EOT response | Sustained response |
| Ferri | 1993 | 15 | 2 MIU IFN/d (1 m) – 2 MIU IFN × 3/w (5 m) | Yes | 6 | 80% | |
| Ferri | 1993 | 26 | 2 MIU IFN/d (1 m) – 2 MIU IFN × 3/w (5 m) | Yes | 6 | 100% | 0 |
| Marcellin | 1993 | 2 | 3 MIU IFN × 3/w | 6 | 50% | ||
| Johnson | 1993 | 4 | 1-10 MIU IFN | No | 2-12 | 75%1 | |
| Misiani | 1994 | 27 | 1.5 MIU IFN × 3/w (1 w) – 3 MIU IFN × 3/w (23 w) | No | 6 | 60% | 0 |
| Dammacco | 1994 | 15 | 3 MIU IFN × 3/w | No | 12 | 53.30% | 25% |
| 16 | 3 MIU IFN × 3/w | Yes | 12 | 52.90% | 33.30% | ||
| Johnson | 1994 | 14 | Variable IFN | No | 01 | ||
| Mazzaro | 1994 | 18 | 3 MIU IFN × 3/w | No | 28% | ||
| Mazzaro | 1995 | 18 | 3 MIU IFN × 3/w | No | 6 | 28% | 11% |
| 18 | 3 MIU IFN × 3/w | No | 12 | 39% | 22% | ||
| Casaril | 1996 | 25 | 6 MIU IFN × 3/w | No | 6 | 52%2 | |
| Cohen | 1996 | 20 | 3 MIU IFN × 3/w | 60%3 | 9%3 | ||
| Akriviadis | 1997 | 20 | 3-5 MIU IFN × 3/w | No | 6-12 | 65%2 | 33%2 |
| Casato | 1997 | 31 | 3 MIU IFN/d (3 m) – 3 MIU IFN × 3/w (≥ 9 m) | No | ≥ 12 | 62% |
CS: corticosteroids; MIU: millions of international units; d: daily; m: months; w: week; EOT: end of treatment; s: Kidney function improvement;
2
: Cryoglobulins disappearance,
3
: both complete and partial MC syndrome response. From: Zignego A.L. Postgraduate Course of the 41st Annual Meeting of the EASL, 2006, modified.