Table 5.
Smoking in controls, Barrett’s oesophagus and oesophageal adenocarcinoma patients
| Controls |
Barrett's oesophagus |
Oesophageal adenocarcinoma |
|||||
| No. | No. | Adjusted1 OR (95% CI) | Further adjusted for GOR OR (95% CI) | No. | Adjusted1 OR (95% CI) | Further adjusted for GOR OR (95% CI) | |
| Smoking status (5 yr prior to interview) | |||||||
| Never2 | 102 | 87 | 1.00 | 1.00 | 46 | 1.00 | 1.00 |
| Ex-smoker | 107 | 85 | 0.97 (0.63 to 1.49) | 0.86 (0.53 to 1.40) | 99 | 1.85 (1.15 to 2.97) | 1.72 (1.06 to 2.81) |
| Current smoker | 45 | 50 | 1.27 (0.74 to 2.17) | 1.41 (0.77 to 2.58) | 77 | 4.64 (2.64 to 8.17) | 4.84 (2.72 to 8.61) |
| No. of cigarettes smoked per day | |||||||
| Never2 | 102 | 87 | 1.00 | 1.00 | 46 | 1.00 | 1.00 |
| < 15 | 54 | 41 | 0.94 (0.57-1.57) | 0.98 (0.55 to 1.75) | 44 | 1.85 (1.07-3.20) | 1.87 (1.06 to 3.28) |
| 15-20 | 51 | 41 | 0.98 (0.58-1.65) | 0.94 (0.52 to 1.69) | 67 | 3.14 (1.83-5.37) | 3.05 (1.76 to 5.30) |
| > 20 | 49 | 53 | 1.32 (0.78-2.22) | 1.16 (0.65 to 2.09) | 66 | 2.92 (1.68-5.10) | 2.72 (1.54 to 4.80) |
| Duration of smoking (yr) | |||||||
| Never2 | 102 | 87 | 1.00 | 1.00 | 46 | 1.00 | 1.00 |
| < 20 | 47 | 28 | 0.72 (0.41 to 1.28) | 0.72 (0.38 to 1.38) | 38 | 1.92 (1.07 to 3.44) | 1.91 (1.05 to 3.48) |
| 20-35 | 55 | 57 | 1.21 (0.74 to 1.98) | 1.09 (0.62 to 1.90) | 54 | 2.08 (1.21 to 3.58) | 1.94 (1.11 to 3.38) |
| > 35 | 53 | 51 | 1.18 (0.70 to 1.98) | 1.18 (0.66 to 2.11) | 85 | 3.74 (2.18 to 6.40) | 3.71 (2.14 to 6.42) |
| Years since quitting smoking | |||||||
| Never2 | 102 | 87 | 1.00 | 1.00 | 46 | 1.00 | 1.00 |
| < 26 | 27 | 29 | 1.27 (0.74 to 2.19) | 1.42 (0.78 to 2.60) | 36 | 4.72 (2.68 to 8.31) | 4.89 (2.74 to 8.71) |
| 26-41 | 40 | 32 | 1.26 (0.68 to 2.33) | 1.11 (0.56 to 2.20) | 29 | 2.68 (1.42 to 5.07) | 2.51 (1.30 to 4.83) |
| > 41 | 40 | 24 | 1.02 (0.58 to 1.81) | 0.89 (0.47 to 1.70) | 34 | 1.52 (0.82 to 2.85) | 1.40 (0.74 to 2.66) |
| Pack years of smoking | |||||||
| Never2 | 102 | 87 | 1.00 | 1.00 | 46 | 1.00 | 1.00 |
| < 15 | 48 | 36 | 0.92 (0.54 to 1.57) | 0.94 (0.51 to 1.72) | 30 | 1.39 (0.76 to 2.55) | 1.39 (0.75 to 2.58) |
| 15-40 | 55 | 47 | 1.01 (0.61 to 1.67) | 0.92 (0.52 to 1.63) | 68 | 2.95 (1.74 to 5.00) | 2.84 (1.66 to 4.86) |
| > 40 | 51 | 52 | 1.28 (0.76 to 2.17) | 1.23 (0.68 to 2.21) | 79 | 3.48 (2.01 to 6.02) | 3.34 (1.91 to 5.83) |
| Cigar | |||||||
| Never | 234 | 204 | 1.00 | 1.00 | 194 | 1.00 | 1.00 |
| Ever | 22 | 18 | 0.84 (0.41 to 1.71)3 | 0.73 (0.33 to 1.61)3 | 29 | 1.30 (0.67 to 2.53)3 | 1.22 (0.61 to 2.43)3 |
| Pipe | |||||||
| Never | 233 | 194 | 1.00 | 1.00 | 182 | 1.00 | 1.00 |
| Ever | 23 | 28 | 1.68 (0.88 to 3.20)3 | 1.31 (0.64 to 2.68)3 | 41 | 1.64 (0.88 to 3.06)3 | 1.45 (0.77 to 2.75)3 |
GOR: gastro-oesophageal reflux; OR: odds ratio; CI: confidence interval.
1
Adjusted for sex, age at interview date, body mass index 5 yr prior to the interview date, alcohol intake (grams), years of full-time education and job type (manual, non-manual).
2
Never smoked, smoked less than 100 cigarettes in lifetime or smoked less than 1 cigarette per day for 6 mo in their lifetime
3
Adjusted for use of other tobacco products e.g. cigarettes, pipe or cigar respectively.