Level of D-lactate (A) and DAO (B) between the model and control groups at different time points. Y axis represents the value of D-lactate and DAO with 95% confidence. A: Model at the 12th wk vs model at the 8th wk, t = 3.67, P = 0.002; model at the 16th wk vs model at the 12th wk, t = 6.29, P < 0.001; B: Model 12th wk vs model at the 8th wk, t = 3.13, P = 0.006; model at the 16th wk vs model at the 12th wk, t = 4.28, P = 0.001.