Table 2.
Diagnosis in celiac disease
| Diagnostic criteria used in celiac disease | Diagnostic propose for celiac disease | Comments |
| Serological test: | With classical symptoms: | Positive serology supports a diagnosis of CD, but they are not |
| Tissue transglutaminase antibody (tTGA) | Serological test: | essential. Compatible with HLA-DQ2/D8 testing and identify |
| Endomysial antibody (EMA) | Tissue transglutaminase antibody (tTGA) | individuals for further biopsy evaluation. Small bowel biopsy |
| Gliadin antibodies (AGA) | Endomysial antibody (EMA) | is critical in symptomatic patients with negative serology for |
| Total IgA | Gliadin antibodies (AGA) | CD and with HLA compatible with the disease |
| Endoscopy | HLA-DQ2/DQ8 testing | Determination of HLA typing as a first step in diagnosis in CD family |
| Capsule endoscopy (with adequate pathological interpretation) | Adequate number of biopsies and well oriented. Estimate lymphocyte infiltration and partial or total villus atrophy | |
| Without classical symptoms HLA-DQ2/DQ8 testing | Primordial role of HLA-typing if serology is negative and with biopsy refused or equivocal to identify individuals | |
| Serologic test: | Adequate number of biopsies and well oriented. Estimate | |
| Tissue transglutaminase antibody (tTGA) | lymphocyte infiltration and partial or total villous atrophy | |
| Endomysial antibody (EMA) | ||
| Gliadin antibodies (AGA) | ||
| Capsule endoscopy (with adequate pathological interpretation) |