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VPCs of TT and T-DM1 concentrations for the reduced model fit to data from a rat PK study with 0.3, 3.0, and 20 mg/kg T-DM1DAR 3.1 and b cynomolgus monkey PK study with 10 mg/kg q3w and 30 mg/kg T-DM1DAR 3.1. For each VPC, the shaded area is the 50th percentile with 95% CI, and the solid red line is the median of the observed data (blue circles). VPC visual predictive check, TT total trastuzumab, T-DM1 trastuzumab emtansine, PK pharmacokinetic, DAR drug-to-antibody ratio
