Fig. 6.

The sensitivity of the model to various parameters was assessed by changing the values in the baseline model over a 10-fold higher and lower range (100-fold range in total). Simulations were performed with a dose of 3 mg/kg adalimumab and the simulated plasma concentrations at each parameter value are shown by lines with the clinical data from Weisman et al. (22) and den Broeder et al. (23) shown as dots