Table 3.

Relationship of mortality with uric acid, as a continuous variable and by uric acid quintile, for various levels of adjustment

N patients = 6,252, N deaths = 516	Model 1	Model 2	Model 3	Model 4	Model 5	Model 6
Per 1 mg/dL uric acid	0.86 (0.80–0.92)	0.90 (0.84–0.96)	0.92 (0.86–0.98)	0.96 (0.90–1.02)	0.95 (0.89–1.01)	0.92 (0.86–0.99)
Quintile Model
2.1–6.5 mg/dL	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)	1.00 (ref.)
6.6–7.2 mg/dL	0.82 (0.61–1.10)	0.88 (0.66–1.16)	0.88 (0.66–1.18)	1.02 (0.77–1.36)	0.99 (0.75–1.32)	0.94 (0.70–1.27)
7.3–8.0 mg/dL	0.70 (0.54–0.93)	0.77 (0.60–1.01)	0.85 (0.65–1.10)	0.98 (0.74–1.29)	0.96 (0.73–1.26)	0.89 (0.67–1.19)
8.1–8.8 mg/dL	0.60 (0.45–0.80)	0.72 (0.54–0.96)	0.79 (0.60–1.06)	0.96 (0.71–1.29)	0.93 (0.68–1.25)	0.84 (0.61–1.16)
8.9–16.4 mg/dL	0.57 (0.43–0.76)	0.67 (0.51–0.89)	0.70 (0.53–0.93)	0.86 (0.64–1.16)	0.82 (0.61–1.10)	0.74 (0.55–1.02)

Cox model hazard ratios (95 % confidence interval) of all-cause mortality

Model 1: stratified by phase, and accounting for facility clustering effects

Model 2: Model 1 + adjusted for age, gender, and years on dialysis

Model 3: Model 2 + 12 comorbidities listed in Table 1

Model 4: Model 3 + serum albumin, creatinine, dry weight, nPCR, cachexia, white blood cell count

Model 5: Model 4 + hemoglobin, calcium*phosphorus product, single pool Kt/V

Model 6: Model 5 + allopurinol use