Table 2. Biomarker correlation summary.

For each biomarker pairing, Spearman Rho Correlation Coefficients and p-values are provided. Black boxes indicate non-applicable analysis same marker correlations.

		TEM-1	PDGFR	Fibronectin	CAIX	HIF2α	Collagen I	Collagen IV
TEM-1	Correlation1		.624**	.293**	.168**	.284**	.431**	.310**
	Sig. (2-tailed)		<0.001	<0.001	0.004	<0.001	<0.001	<0.001
PDGFR	Correlation1	.624**		.333**	.240**	.449**	.652**	.497**
	Sig. (2-tailed)	<0.001		<0.001	<0.001	<0.001	<0.001	<0.001
Fibronectin	Correlation1	.293**	.333**		0.058	.543**	.469**	.449**
	Sig. (2-tailed)	<0.001	<0.001		0.33	<0.001	<0.001	<0.001
CAIX	Correlation1	.168**	.240**	0.058		.119*	.127*	0.061
	Sig. (2-tailed)	0.004	<0.001	0.33		0.04	0.03	0.3
HIF2α	Correlation1	.284**	.449**	.543**	.119*		.465**	.302**
	Sig. (2-tailed)	<0.001	<0.001	<0.001	0.04		<0.001	<0.001
Collagen I	Correlation1	.431**	.652**	.469**	.127*	.465**		.644**
	Sig. (2-tailed)	<0.001	<0.001	<0.001	0.03	<0.001		<0.001
Collagen IV	Correlation1	.310**	.497**	.449**	0.061	.302**	.644**
	Sig. (2-tailed)	<0.001	<0.001	<0.001	0.3	<0.001	<0.001

1 Correlations were classified as follows: ** indicating highly significant (P<0.01) and * indicating significant (0.05 > P > 0.01).