Table 3. Summary of TAPPS model development.
Results from multivariate Cox Proportional Hazards modeling for the full model (all pre-qualified markers entered into model) and the minimal model (markers rationally chosen from full model) with indicated Model P values. Provided are the marker in the model, multivariate HR, 95%CI, p-values and model coefficient (if applicable). Cox Proportional Hazard modeling results based on continuous TAPPS scores for both training set and validation set are provided for the full and minimal models.
| Model | Marker | HR | 95%CI | P-value | Coefficient |
|---|---|---|---|---|---|
| Full (Individual Markers) |
TEM1 Stroma | 0.41 | 0.24-0.69 | 0.001 | −0.89 |
| TEM1 Tumor Vessel | 3.27 | 1.35-7.95 | 0.009 | 1.19 | |
| HIF2α Stromal Vessel | 0.47 | 0.25-0.88 | 0.02 | −0.76 | |
| Collagen IV Tumor | 1.86 | 1.08-3.21 | 0.03 | 0.62 | |
| FN Stroma | 2.29 | 1.23-3.21 | 0.009 | 0.83 | |
| Full (TAPPS Score) |
TAPPS (Training)n=330 | 1.76 | 1.44-2.15 | <0.001 | NA |
| TAPPS (Validation)n=164 | 1.38 | 1.02-1.88 | 0.04 | NA | |
| TAPPS (w/Clinical)n=494 | 1.66 | 1.37-2.03 | <0.001 | NA | |
| TAPPS (Stage II)n=126 | 1.75 | 1.22-2.52 | 0.002 | NA | |
| TAPPS (Stage III/IV)n=235 | 1.40 | 1.14-1.73 | 0.001 | NA | |
| Minimal (Individual Markers) |
TEM-1 Stroma | 0.58 | 0.36-0.93 | 0.03 | −0.55 |
| Collagen IV Tumor | 1.90 | 1.12-3.25 | 0.02 | 0.64 | |
| FN Stroma | 2.18 | 1.18-4.05 | 0.01 | 0.78 | |
| Minimal (TAPPS Score) |
mTAPPS (Training)n=330 | 2.72 | 1.82-4.08 | <0.001 | NA |
| mTAPPS (Validation)n=164 | 2.66 | 1.26-5.62 | 0.01 | NA | |
| mTAPPS (w/Clinical)n=494 | 2.37 | 1.48-3.81 | <0.001 | NA | |
| mTAPPS (Stage II)n=126 | 3.99 | 1.71-9.29 | 0.001 | NA | |
| mTAPPS (Stage III/IV)n=234 | 1.94 | 1.27-2.98 | 0.002 | NA |