Figure 1. Metareview of Reported Mutation Frequencies and our BRAF Genotyping Results in Langerhans cell histiocytosis.

*A total of 13 case reports/series are summarized (see methods). Abbreviations: LCH, Langerhans cell histiocytosis; mut., mutated; N, number of tested samples. In the summary line, the average of all studies is provided along with the 95% confidence interval assuming a binomial distribution for all included cases (line).