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. 2014 Jun 2;5(12):4071–4086. doi: 10.18632/oncotarget.1705

Figure 2. MLN8237 inhibits AURKA and induces mitotic arrest in gastrointestinal stromal tumor (GIST) cell lines.

Figure 2

(A) Immunoblotting with an anti-phospho-Aurora A (Thr288) antibody revealed inhibition of AURKA autophosphorylation in GIST cell lines synchronized by exposure to nocodazole and then treated with MLN8237. (B) Immunoblotting of three AURKA-expressing GIST cell lines with an anti-phospho-HistoneH3 (Ser10) (pHisH3) antibody revealed a dose-dependent induction of pHisH3 after treatment with MLN8237 for six days.