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. 2014 Jun 2;5(12):4071–4086. doi: 10.18632/oncotarget.1705

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Copyright: © 2014 Yeh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Treatment with MLN8237 inhibits AURKA and results in growth inhibition and apoptosis in gastrointestinal stromal tumor (GIST) cell lines. The viability of GIST882, GIST48, and GIST430 cells after treatment with various concentration of MLN8237 (MLN) for six days was measured with (A) the TACS™ MTT cell proliferation assay (expressed as a percentage of viability under controlled culture conditions) and (B) a trypan blue exclusion assay (expressed as viable cell number). (C) Apoptosis assay. Three GIST cell lines were treated with various concentration of MLN8237 (MLN) for six days. The percentage of apoptotic cells was determined using Annexin V-FITC/propidium iodide (PI) staining. All data represent the mean ± SD of three independent experiments. *P < 0.05.