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. 2014 May 20;5(12):4257–4268. doi: 10.18632/oncotarget.1991

Figure 6. Low levels of TP53INP1 expression in tumor tissues correlate with high levels of N-Myc expression and poor prognosis in neuroblastoma patients.

Figure 6

A, RT-PCR studies were performed in 201 primary human neuroblastoma from Children's Oncology Group (COG) with primers targeting TP53INP1 or N-Myc. Correlation between TP53INP1 expression and N-Myc expression in the tumor tissues was analysed by Pearson's correlation. B, Kaplan–Meier survival analysis was performed based on the level of expression of TP53INP1 in the 201 neuroblastoma patients. The level of expression was considered high or low in relation to the median or lower decile of TP53INP1 expression of all tumors analyzed. C and D, correlation between TP53INP1 expression and N-Myc expression was analysed in 88 and 476 human neuroblastoma samples in publically available microarray gene expression datasets of Versteeg (C) and Kocak (D). E and F, Kaplan–Meier survival analysis was performed based on the level of TP53INP1 expression in the 88 and 476 neuroblastoma patients in the Versteeg dataset (E) and the Kocak dataset (F). The level of expression was considered high or low in relation to the median or lower decile of TP53INP1 expression of the tumors analyzed.