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. 2014 May 29;5(12):4467–4479. doi: 10.18632/oncotarget.2039

Figure 7. In vivo growth kinetics and tumor cell apoptosis of HROC24 tumors in NMRI Foxn1mice with or without local treatment.

Figure 7

(A) Therapy was performed by repetitive local application of HDPs C7A or C7A-D21K (1 mg/kg bw) every third day (a total of 9 injections) (n=5 per group). Tumor-carrying control animals received either equivalent volumes of peptide NK11 or saline (n=5 per group). Tumor volumes are given as x-fold increase vs. day 0 (Vt/V0) (start of treatment) ± SD. *p<0.05 vs. PBS. (B) Representative immunofluorescence staining of apoptotic cells within HROC24 tumors. Cryopreserved tumor sections were stained with anti-M30 CytoDeath antibody, followed by anti-mouse IgG FITC antibody and nuclear DAPI as described in material and methods.