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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2014 Apr 16;22(11):2919–2938. doi: 10.1016/j.bmc.2014.04.014

Figure 2.

Figure 2

(A) FXR binding activities of GW4064, E16, and lithocholic acid in an FXR TR-FRET binding assay. (B) FXR agonistic activities (GW4064, E16, or lithocholic acid alone) and antagonistic activities (E16 and lithocholic acid in the presence of 400 nM GW4064) in a cell-based FXR transactivation assay. GW4064 and lithocholic acid were used as agonistic and antagonistic controls, respectively.