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. 2014 Aug 28;8:98. doi: 10.3389/fncom.2014.00098

Figure 5.

Figure 5

Recovery of spike counts following hyperpolarization. Spike counts (mean ± s.e.m.) in response to 1 (black), 2 (red), and 4 EPSGs (blue) at −65 mV and as a function of elapsed time at −80 mV. (A) Spike counts in response to rEPSGs (left) and aEPSGs (right) in two individual neurons. Large symbols represent means, and small symbols represents spike counts for a single EPSG event, offset slightly in some cases to avoid overlap with other data points. The cell illustrating aEPSGs was chosen because it had the highest spike counts at 800 ms among 26 neurons. (B) Spike counts (mean ± s.e.m.) in response to rEPSG (left) and aEPSG (right) events averaged across the population of recorded neurons. Of 26 neurons tested with aEPSGs, only 13 were tested at 100 ms. (C) Spike counts in response to aEPSGs did not recover in the presence of nickel (300 μM). (D) Population spike counts in response to aEPSG events, as in recordings in the whole cell configuration in (B), but for a separate population of 11 neurons recorded with perforated-patch pipettes.