Table 4.
Clinical associations not found in the Original Medline 1000 dataset
| ICD-9 code | Description | ICD-9 code | Description | Association p value derived from clinical dataset |
Clinically surprising? | Citations found (PMID)† |
|---|---|---|---|---|---|---|
| 1st percentile (highest ranked associations) | ||||||
| 719.46 | Joint pain, lower leg | 848.9 | Sprain and Strain, unspecified site | <5×10−324 | No | 21549978 9343643 |
| 172.1 | Malignant melanoma of skin and eyelid | 190.3 | Malignant neoplasm of conjunctiva | <5×10−324 | No | 21478094 10811089 |
| 250.71 | Diabetes with peripheral circulatory disorders | 337.1 | Peripheral autonomic neuropathy | <5×10−324 | No | 20724598 2779736 |
| 153.0 | Malignant neoplasm of colon | 230.4 | Carcinoma in situ of rectum | <5×10−324 | No | 21125511 6894080 |
| 309.28 | Adjustment disorder with mixed anxiety and depressed mood | 724.2 | Lumbago | <5×10−324 | No | 21665125 18673099 |
| 25th percentile | ||||||
| 535.50 | Gastritis and gastroduodenitis | 787.6 | Fecal incontinence | 4.8 x10 −68 | * | 16712555 |
| 518.0 | Pulmonary collapse | 876.1 | Open wound of back | 9.8×10−68 | No | 17554992 |
| 474.0 | Chronic tonsillitis and adenoiditis | 558.9 | Non-infectious gastroenteritis and colitis | 7.6×10−67 | Yes | 12080166 |
| 377.39 | Optic neuritis | 432.1 | Subdural hemorrhage | 7.8×10−67 | Yes | |
| 307.59 | Eating disorder | 564.01 | Slow transit constipation | 9.9×10−68 | No | 19139750 10925980 |
| 50th percentile | ||||||
| 600 | Hyperplasia of prostate | 747.61 | Gastrointestinal vessel anomaly | 1.89×10−23 | Yes | |
| 296.20 | Major depressive affective disorder | 734 | Pes planus | 3.5×10−23 | Yes | |
| 164.8 | Malignant neoplasm of mediastinum | 427.89 | Cardiac dysrhythmia | 3.7×10−22 | No | 15284266 21387697 |
| 227.0 | Benign neoplasm of adrenal gland | 788.41 | Urinary frequency | 5.3×10−22 | Yes | |
| 250.51 | Type 1 diabetes with ophthalmic manifestations | 959.5 | Finger injury | 1.9×10−21 | * | 18820219 |
| 75th percentile | ||||||
| 217 | Benign neoplasm of breast | 569.85 | Angiodysplasia of intestine with hemorrhage | 4.7×10−06 | Yes | |
| 362.31 | Central retinal artery occlusion | 836.0 | Tear of medial cartilage or meniscus of knee | 4.7×10−06 | Yes | |
| 373.32 | Contact and allergic dermatitis of eyelid | 656.90 | Unspecified fetal and placental problem, affecting management of mother, unspecified as to episode of care or not applicable | 4.7×10−06 | Yes | |
| 110.5 | Dermatophytosis of the body | 246.2 | Thyroid cyst | 4.7×10−06 | Yes | 1607406 |
| 011.90 | Pulmonary tuberculosis | 701.1 | Keratoderma, acquired | 4.8×10−06 | Yes | 9828554 |
| 100th percentile (lowest ranked associations) | ||||||
| 459.9 | Circulatory system disorder | 684 | Impetigo | 0.99 | * | 22642914 |
| 171.9 | Malignant neoplasm of connective and other soft tissue | 333.1 | Essential tremor | 0.99 | Yes | |
| 189.0 | Malignant neoplasm of kidney | 795.5 | Nonspecific reaction to test for tuberculosis | 0.99 | Yes | 20623161 |
| 225.3 | Benign neoplasm of spinal cord | 558.9 | Non-infectious gastroenteritis and colitis | 0.99 | Yes | |
| 378.31 | Hypertropia | 722.10 | Displacement of lumbar intervertebral disc without myelopathy | 0.99 | Yes | |
These were selected from the left-most area in figure 3A. Associations become more clinically surprising as their ranking decreases. Whether an association was clinically surprising was independently determined by two physicians (κ statistic 0.75; 95% CI 0.48 to 1.01). A manual search for citations by each physicians revealed potential associations that were not detected with the automated approach using MetaMap.
*Opinions for which the physicians differed.
†If only one citation is listed, it means that only one reviewer found a citation that supported the association. If two are listed, each reviewer found at least one citation to support the association. If none are listed, neither reviewer was able to find a citation to support the association.
ICD-9, International Classification of Disease, V.9; PMID, PubMed Identifier.