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Activation of β-catenin impairs the generation and migration of Olig1 and Olig2-positive cells. Transverse sections of spinal cord from E13.5 (a–a′, e–e′), E14.5 (b–b′, f–f′), E16.5 (c–c′, g–g′), and E18.5 (d–d′, h–h′), WT (a–h), and CatG/+ (a′–h′) mice are subjected to ISH with Olig1 and Olig2 riboprobes as OL lineage cell markers. The total number of Olig1 and Olig2-positive cells in CatG/+ mice is severely reduced.
