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. 2014 Aug 21;6(8):3250–3270. doi: 10.3390/v6083250

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

NS3 interacts with trafficking pathway protein Annexin 2 (Calpactin, p11) and ESCRT (endosomal complex required for transport) pathway protein Tsg101 and Nedd-4. (A) NS3 is proposed to adopt a membrane spanning topology. (B) Co-localization of Annexin2 (p11) and NS3 in the infected cell. (C) Co-localization of Tsg101 and NS3 in the infected cell. Transmission electron micrographs (TEM) of wild-type virion egress (D) and N-terminal NS3-p11 interacting domain mutant (E) that demonstrate trafficking aberration in the NS3 mutant. Adapted from [17,18,75].