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. 2014 Aug 21;6(8):3293–3310. doi: 10.3390/v6083293

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Pattern of Ad5-CGW-CK2-mediated GFP expression at the site of stereotactic delivery. Confocal immunohistochemical analysis of GFP expression by Ad5-CGW-CK2 stereotactically delivered to mouse SN (A) and STR (B) results in striking neuronal tropism. (A) Low-power image of the injected SN. Only neurons are positive for GFP expression. (a,b,c) Magnification of the region outlined in (A). A TH (red, a)/GFP (green, b) double-positive neuron is clearly visible surrounded by uninfected dopaminergic (DA) neurons (merge, c). (B) When Ad5-CGW-CK2 is delivered to the STR, GFP-expressing cells with neuronal morphology are observed. Despite thick (40 µm) sections and assessment of numerous slices around the injection site, no non-neuronal GFP expressing cells could be appreciated in the brains of animals receiving Ad5-CGW-CK2. Red = TH. Green = GFP. Bar in A = 500 μm. Bar in b (for a, b, c) = 2.5 μm. Bar in B = 100 μm.