Fig. 3.

MRI features in tremor–ataxia with central hypomyelination (TACH). Characteristic MRI images in two subjects: cases 5 (a) and 7 (b) (the least and most affected patients, at ages 11 and 21 years, respectively). The MRI show diffuse hypomyelination with diffusely increased T2 signal, isointense or hyperintense T1 signal, with relative sparing of arcuate fibers and optic radiations. Thinning of the corpus callosum is a constant feature. In the most clinically affected patients, such as in case 7, there is some periventricular deep white matter rarefaction on FLAIR images, as well as atrophy of the cerebellum