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. Author manuscript; available in PMC: 2014 Aug 28.
Published in final edited form as: Drug Test Anal. 2012 Aug 13;5(1):27–45. doi: 10.1002/dta.1390

Table 7.

Summary of known effects of Δ9-THC and other cannabimimetics on neuronal development of the CNS, subdivided on effects in neuronal circuitry, and effects on neurotransmitter signalling. All experiments were performed in rat

Compound Stage Area Effect on neuronal development of developing CNS in rat Refs
Δ9-THC, WIN-55,212-2 E14 Mesencephalic neuron cultures Modulates the activity of TH 155,158,199-201
Δ9-THC E5-P20 Cerebellum Modulates transcription of glutamate receptor subunits 172
Δ9-THC, WIN 55,212-2 E15-P9 Cortex Reduces levels of glutamatergic neurotransmitters 195,197
WIN55,212-2 E5-20 Hippocampal neuron cultures Reduction in glutamate outflow 196
Δ9-THC, WIN 55,212-2 E15-P9 Cortex, amygdala Reduces levels of noradrenergic neurotransmitters 193,197
Δ9-THC – Nucleus accumbens, caudal putamen and rostral dorsal striatum Inhibition of PENK mRNA expression 194,202-204
HU-210 P4 Cerebellar neurons GABA mRNA expression 205
Δ9-THC – Diencephalon, hippocampus, midbrain raphe nuclei and septum Reduces serotonin levels 171