Table 1.
Association of clinical and laboratory parameters with PTEN methylation status
| Parameter | PTEN unmethylated n = 51 | PTEN methylated n = 7 | P value |
|---|---|---|---|
|
Heavy chain |
|
|
0.8 |
| IgG |
40 |
6 |
|
| IgA |
10 |
1 |
|
| IgM |
1 |
0 |
|
|
Light chain |
|
|
0.04 |
| Kappa |
25 |
7 |
|
| Lambda |
16 |
0 |
|
|
Stage |
|
|
|
| I |
14 |
4 |
0.3 |
| II |
10 |
1 |
|
| III |
25 |
2 |
|
|
Age (mean in years) |
67.6 ± 13.0 |
69 ± 10.1 |
0.7 |
|
White blood cells (mean n°x10^3/mcL) |
6.58 ± 2.2 |
6.0 ± 2.9 |
0.5 |
|
Hemoglobin (mean in g/dL) |
10.2 ± 2.1 |
11.2 ± 1.9 |
0.2 |
|
Platelets (mean n°x10^3/mcL) |
235 ± 95 |
210 ± 65 |
0.5 |
|
Lactate dehydrogenase (mean in U/L) |
379 ± 186 |
200 ± 40 |
0.01 |
|
β2-microglobuline (mg/dL) |
5.3 ± 4.5 |
5.3 ± 5.4 |
0.9 |
|
Albumin (mean in g/dL) |
3.6 ± 0.7 |
3.9 ± 0.8 |
0.3 |
|
Serum creatinine (mean in mg/dL) |
2.0 ± 2.35 |
1.0 ± 0.6 |
0.2 |
|
Calcium (mean in mg/dL) |
6.0 ± 2.5 |
7.1 ± 2.5 |
0.3 |
|
Protein (mean in g/L) |
8.5 ± 1.8 |
8.8 ± 1 |
0.66 |
|
Plasma cells (mean in %) |
52 ± 31 |
58 ± 24 |
0.6 |
|
Cytogenetic risk |
|
|
0.68 |
| Standard |
31 |
5 |
|
| Intermediate |
15 |
1 |
|
| High | 5 | 1 |