Table 1.
Upregulated genes in A/J myotubes compared to WT.
| Gene symbol | Accession | Fold regulation | P-value | Description |
|---|---|---|---|---|
| CASP1 | NM_009807 | 8.074 | 0.005283 | Caspase 1; IL-1β converting enzyme |
| IKBKE | NM_019777 | 2.555 | 0.005499 | Inhibitor of kappa light polypeptide gene enhancer I B-cells kinase epsilon (IKK-ε) |
| TNFSF14 | NM_019418 | 1.8417 | 0.005601 | Tumor necrosis factor ligand 14 |
| RIPK1 | NM_009068 | 1.4682 | 0.005616 | TNFRSF-interacting serine–threonine kinase 1 |
| IL1R1 | NM_008362 | 1.3731 | 0.00641 | Interleukin 1 receptor, type I |
| NFKBIA | NM_010907 | 1.4234 | 0.008922 | Nuclear factor of kappa light polypeptide gene enhancer I B-cells inhibitor, alpha (IκBα) |
| MALT1 | NM_172833 | 2.9197 | 0.010395 | Mucosa associated lymphoid tissue lymphoma translocation gene 1 |
| MAP3K1 | NM_011945 | 1.3371 | 0.012835 | Mitogen-activated protein kinase kinase kinase 1 |
| BCL10 | NM_009740 | 1.3743 | 0.014181 | B-cell leukemia/lymphoma 10 |
| IL1B | NM_008361 | 1.5819 | 0.020047 | Interleukin 1 beta |
| AKT1 | NM_009652 | 1.5422 | 0.022827 | Thymoma viral proto-oncogene 1 |
| TLR9 | NM_031178 | 1.5148 | 0.035545 | Toll-like receptor 9 |
| JUN | NM_010591 | 1.5488 | 0.044134 | Jun oncogene; activator protein 1 |
| SLC44A2 | NM_152808 | 1.3709 | 0.04511 | Solute carrier family 44 member 2 |
| RELB | NM_009046 | 1.4056 | 0.060459 | Avian reticuloendotheliosis viral oncogene |
| CFLAR | NM_009805 | 1.421 | 0.071965 | CASP8 and FADD-like apoptosis regulator |
| IRAK1 | NM_008363 | 2.096 | 0.077476 | Interleukin-1 receptor associated kinase |
| FASLG | NM_010177 | 1.4813 | 0.084698 | Fas ligand (TNF superfamily member 6) |
| GJA1 | NM_010288 | 3.9818 | 0.110953 | Gap junction protein, alpha 1 |
| FADD | NM_010175 | 1.6649 | 0.146432 | Fas (TNFRSF6)-associated via death domain |
| TRIM13 | NM_023233 | 1.3004 | 0.147326 | Tripartite motif-containing 13 |
| ICAM1 | NM_010493 | 1.3983 | 0.153045 | Intercellular adhesion molecule 1 |
| ELK1 | NM_007922 | 1.3561 | 0.159154 | Member of ETS oncogene family |
| LPAR1 | NM_010336 | 1.3657 | 0.159469 | Lysophosphatidic acid receptor 1 |
| HMOX1 | NM_010442 | 2.5448 | 0.206157 | Heme oxygenase (decycling) 1 |
| TLR3 | NM_126166 | 1.6474 | 0.212925 | Toll-like receptor 3 |
| LTA | NM_010735 | 1.3579 | 0.264798 | Lymphotoxin A |
| TLR4 | NM_021297 | 1.3579 | 0.264798 | Toll-like receptor 4 |
| TNFRSF1A | NM_011609 | 1.3579 | 0.264798 | Tumor necrosis factor receptor superfamily member 1a |
| EDARADD | NM_133643 | 1.3122 | 0.274549 | Ectodysplasin-A receptor-associated death domain |
| CSF2 | NM_009969 | 1.8589 | 0.314809 | Colony stimulating factor 2 (granulocyte–macrophage) |
| IFNB1 | NM_010510 | 1.5772 | 0.431395 | Interferon beta 1, fibroblast |
| IL6 | NM_031168 | 1.428 | 0.505621 | Interleukin 6 |
| CCL2 | NM_011333 | 1.4446 | 0.615915 | Chemokine (C-C motif) ligand 2 |
| TLR6 | NM_011604 | 1.325 | 0.71502 | Toll-like receptor 6 |
| IFNG | NM_008337 | 1.3409 | 0.990221 | Interferon gamma |
qRT-PCR array of A/J H-2K and WT H-2K myotubes. Inflammatory genes from the array that were upregulated >1.3-fold were included and are shown with P-values.