Table 3. Phenotypes associated with JmjC depletion studies in model organisms.
–, no orthologue; ND, not determined or no data.
| Phenotype in depletion studies | ||||
|---|---|---|---|---|
| JmjC | Mus musculus | Danio rerio | Caenorhabditis elegans | Drosophila melanogaster |
| KDM2B | Partial peri/postnatal lethal, lowered sperm count, defective neural tube development [112] | ND | ND | Embryonic lethal [113] |
| KDM3A | Metabolic defects, adult obesity and male infertility [114–116] | – | – | ND |
| KDM4A | Impaired cardiac stress response [60] | ND | Increased germline apoptosis [117] | Abnormal male wing extension and reduced male lifespan [118] |
| KDM4D | No detected phonotypical change [119] | ND | ||
| KDM5A | Decreased apoptosis in HSC and myeloid progenitors [120] | ND | Defects in vulva formation and reduced lifespan [83,121] | Developmental defects [122] |
| KDM5B | Embryonic lethal [123] | ND | ||
| KDM5C | Cardiac looping and neuralation defects [124] | Increased neuronal cell death and abnormal dendrite development [90] | ||
| JARID2 | Embryonic lethal [125–127] | ND | – | ND |
| KDM6B | Perinatal lethal and defective lung development [128] | ND | Defective vulva development [129] | Larval lethal [130] |
| KDM6A | Partial male embryonic lethal, defects in neural tube and cardiac development and female embryonic lethal [63,124] | Abnormal posterior development [59] | ||
| PHF2 | Partial neonatal lethal, adipogenesis defects [61] | Detects in brain development [131] | Defects in body movement [97] | – |
| KDM8 | Embryonic lethal [132] | ND | ND | ND |
| JMJD6 | Perinatal lethal with multiple developmental defects [133] | Defects in heart brain, somites and notochord [134] | Mild cell engulfment defects [135] | Enhanced apoptosis in developing eye [136] |