Figure 1.

Rhcg^+/+, Rhcg^+/−, and Rhcg^−/− mice can adapt to HC diet. Blood and urine data were collected in Rhcg^+/+, Rhcg^+/−, and Rhcg ^−/− mice treated for 9 days on the HC diet. All animals showed a transient decrease of blood pH (A) and bicarbonate (B). (C) Titratable acids increased on the HC diet. (D) All mice rapidly increased urinary NH₄⁺ excretion, but Rhcg^−/− had lower NH₄⁺ excretion than Rhcg^+/+ during days 2 and 4 of the HC diet. Values are mean±SEM (n=8 mice) *P≤0.05 (Rhcg^−/− versus Rhcg^+/+), ^#P≤0.05 significantly different from same genotype under control conditions (day 0), ***P≤0.05 significantly different from Rhcg^+/+ mice under same treatment conditions and for the same time point.