Figure 3.

BMI categories showing a U-shaped association with progression of chronic kidney disease in 453,946 United States veterans with eGFR<60 ml/min per 1.73 m². Association of BMI categories with four different outcomes representing progression of CKD: (A) steeper slopes of eGFR versus time (defined as slopes<−4 ml/min per 1.73 m² per year), (B) doubling of serum creatinine or ESRD, (C) projected eGFR<10 ml/min per 1.73 m² or ESRD, and (D) ESRD. Estimates were calculated from a logistic regression model (for steeper slopes) and Cox models (for all other outcomes) adjusted for age, race, comorbidities, medications, and baseline eGFR.