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Overexpression of mutant ANLN causes aberrant podocyte migration. Immortalized undifferentiated cultured human podocytes are stably transfected with tGFP empty vector control, tGFP-tagged WT (ANLNWT), or mutant (ANLNR431C) anillin constructs using the lentivirus gene delivery system. (A and B) Motility of the mutant cell line is significantly increased compared with the wild-type overexpression cell line, and both cell lines migrate faster than the tGFP empty vector control cell line.
