Figure 4.

Severity of initial injury determines shift in capillary size and extent of capillary rarefaction. (A) Distribution of capillary size demonstrates a loss of larger capillaries (>15 µm²) after moderate and severe IRI, with a slight increase in counted small capillaries (<15 µm²) (data represent three mice per group). (B) FMA assessed total capillary cross-sectional area (total perfused area, µm²/high-power field), individual capillary cross-sectional area (µm²), and capillary number (number/high-power field) shows highly significant correlation with day 1 BUN and lower correlation with week 8 BUN.