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Urinary albumin excretion. (A) The UACR is assessed in mice before and after injection of adriamycin for 14 and 28 days. Mice are fed with either doxycycline or vehicle food from days 7 to 28 postinjection (n=6 in AD;PODRDH9+vehicle group; n=5 in AD;PODRDH9+doxycycline group). *P<0.05 compared with AD;PODRDH9+vehicle. (B) Coomassie stain reveals that the proteinuria is mainly albuminuria. The representative gel of two mice in each group is shown. AD, adriamycin; DOX, doxycycline.
