Table 3.
Body weight, serum urea, and creatinine in the adriamycin-induced nephropathy model
| Treatment Group | Mice (n) | Body Weight (g) | Serum Urea Nitrogen (mg/dl) | Serum Creatinine (mg/dl) | |||
|---|---|---|---|---|---|---|---|
| Pregroup | Postgroup | Pregroup | Postgroup | Pregroup | Postgroup | ||
| AD;PODRDH9+vehicle | 6 | 25.15±2.17 | 26.28±1.71 | 26.22±4.86 | 29.16±7.99 | 0.11±0.04 | 0.15±0.04 |
| AD;PODRDH9+doxycycline | 5 | 23.94±1.2 | 27.44±1.63a | 26.41±3.17 | 22.84±4.43 | 0.10±0.02 | 0.14±0.06 |
Body weight was recorded and serum samples were obtained in mice before and after injection of adriamycin for 28 days in both the doxycycline feeding and control groups. Serum creatinine was measured by HPLC-based assay. Pregroups are before the injection of adriamycin, whereas the postgroups are 28 days after injection of adriamycin. AD, adriamycin.
a
P<0.05 compared with mice in the pregroups.