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. 2014 Aug;51(2):169–177. doi: 10.1165/rcmb.2013-0298OC

Figure 6.

Figure 6.

NgBR modulates eNOS coupling through Akt pathway. (A) NgBR overexpression in IPH PAECs increased the basal phosphorylation of eNOS and Akt, as well as vascular endothelial growth factor (VEGF)-stimulated phosphorylation of eNOS and Akt. (B) NgBR knockdown in control PAECs decreased the basal phosphorylation of eNOS and Akt, as well as VEGF-stimulated phosphorylation of eNOS and Akt. Open bar, empty plasmid or NS siRNA transfected unstimulated PAECs; closed bar, plasmid or siRNA transfected unstimulated IPH PAECs; hatched bar, VEGF-stimulated empty plasmid or NS siRNA transfected PAECs; back-hatched bar, VEGF-stimulated, plasmid, or siRNA transfected PAECs. *P < 0.05 compared with the corresponding unstimulated PAECs group for empty, NgBR plasmid or NS siRNA transfected cells; ‡P < 0.05 compared with empty plasmid or NS siRNA transfected, unstimulated PAECs; †P < 0.05 compared with plasmid or siRNA transfected, unstimulated PAECs. Data are shown as mean (± SE).