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. 2014 Aug;51(2):210–222. doi: 10.1165/rcmb.2013-0353OC

Figure 5.

Figure 5.

Zonula occludens (ZO)-1 and ZO-2 expression and localization in WT and C18 KO mice. (A and B) Western blot analysis of whole lung membrane fractions for ZO-1 (A) and ZO-2 (B) shows similar expression levels in WT and C18 KO mice. (C) Immunofluorescence and confocal microscopy reveal increased distance between ZO-1 localization in adjacent cells in MAECMs from C18 KO compared with WT mice on Day 10 (confocal micrographs). Arrows indicate examples of gaps. (D) The distance between ZO-1 staining in adjacent alveolar epithelial cells was significantly higher in C18 KO compared with WT MAECM. *P < 0.05.