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. 2014 Aug;51(2):251–261. doi: 10.1165/rcmb.2013-0452OC

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Copyright © 2014 by the American Thoracic Society

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Figure 3. — Obese-prone rats (closed bars) had significantly heavier body weight (A) and body fat (B) than obese-resistant rats (open bars) regardless of whether they were on a high- or low-fat diet. STZ (gray bars) significantly attenuated weight gain (C) and increased body fat (D) induced by a HFD. Insulin administered daily for 5 weeks (chronic insulin [cINS]) did not restore weight (C) but increased body fat in obese-resistant rats (D, last two bars on right). Each bar represents mean ± SEM (n = 6–14). *P < 0.05.