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. Author manuscript; available in PMC: 2014 Aug 28.
Published in final edited form as: Endocrine. 2010 Nov 19;39(3):235–241. doi: 10.1007/s12020-010-9429-y

Fig. 2.

Fig. 2

Insulin therapy reduced JNK activity in the liver of diabetic rats. JNK activity was determined by phosphorylation status of its substrate c-JUN in a Western blot. To normalize for JNK activity, JNK proteins were examined in cell lysates. Anti-JNK antibody that detects both JNK1 and JNK2 was used. The relative signal levels were determined by densitometry. Each bar represents the mean ± SD (n = 4–6). *P < 0.05 vs. NC; #P < 0.05 vs. DM. NC normal control rats; DM diabetic rats with no therapy; INS diabetic rats treated with insulin