Figure 5.
Ibandronate washout increases calcium spark frequency. A: Line scan representation of the calcium spark measured at baseline, during ibandronate treatment, and during washout. B: Ibandronate treatment and washout significantly (P < 0.05) decreases calcium spark amplitude compared to baseline. C: Ibandronate treatment and washout did not alter calcium spark frequency. D: Calcium spark frequency, normalized to SR calcium load, was significantly increased during ibandronate washout (P < 0.05) compared to baseline and ibandronate treatment.