Table 2.
Grade | |||||
---|---|---|---|---|---|
AE | 1 | 2 | 3 | 4 | 5 |
Palmar-plantar erythrodysesthesia syndrome (hand-foot skin reaction) Definition: A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet |
Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain | Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL | Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL | — | — |
Photosensitivity Definition: A disorder characterized by an increase in sensitivity of the skin to light |
Painless erythema and erythema covering <10% BSA | Tender erythema covering 10–30% BSA | Erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) | Life-threatening consequences; urgent intervention indicated | Death |
Acneiform rash Definition: A disorder characterized by an eruption of papules and pustules, typically appearing in the face, scalp, upper chest, and back |
Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness | Papules and/or pustules covering 10–30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL | Papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated | Papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences | Death |
National Cancer Institute Common Terminology Criteria for Adverse Events (40).
ADL, activities of daily living; AEs, adverse events; BSA, body surface area; CTCAE, National Cancer Institute's Common Terminology Criteria for Adverse Events; IV, intravenous; NSAIDs, nonsteroidal anti-inflammatory drugs.