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. 2014 Sep 1;24(9):1329–1340. doi: 10.1089/thy.2013.0700

Table 2.

CTCAE Grading of Selected TKI-Associated Dermatologic AEs*

  Grade
AE 1 2 3 4 5
Palmar-plantar erythrodysesthesia syndrome (hand-foot skin reaction)
Definition: A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet
Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL
Photosensitivity
Definition: A disorder characterized by an increase in sensitivity of the skin to light
Painless erythema and erythema covering <10% BSA Tender erythema covering 10–30% BSA Erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) Life-threatening consequences; urgent intervention indicated Death
Acneiform rash
Definition: A disorder characterized by an eruption of papules and pustules, typically appearing in the face, scalp, upper chest, and back
Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness Papules and/or pustules covering 10–30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL Papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated Papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences Death
*

National Cancer Institute Common Terminology Criteria for Adverse Events (40).

ADL, activities of daily living; AEs, adverse events; BSA, body surface area; CTCAE, National Cancer Institute's Common Terminology Criteria for Adverse Events; IV, intravenous; NSAIDs, nonsteroidal anti-inflammatory drugs.