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. 2014 May 9;5(13):4651–4664. doi: 10.18632/oncotarget.1701

Figure 4. Memory B cells and cells with a plasma cell phenotype are significantly reduced in colorectal liver metastasis.

Figure 4

(A) CD19+CD20+ cells make up only 2% of CD45+ lymphocytic cells in metastatic tissue (n=6) compared to 6.9% in samples of primary colorectal cancer (n=28) (p<0,05) (B) The percentage of IgD-/CD27+ memory b cells in colorectal liver metastasis (n=6) is significantly lower than in primary tumors (n=28) (9.9% vs. 23.4%, p<0,05) (C) Whereas cells with a plasma cell phenotype were regularly detectable in tumor samples of CRC patients (n=38) they were heavily reduced in metastatic Tissue (n=6) (3.7% compared to 31.7%, p<0,005). (D) B cells with a regulatory phenotype (CD24highCD38high B cells) were rare in the primary tumors, but well detectable in metastatic tissue (1,1% vs. 6,3% of CD19+CD20+ cells, p<0,05).